Produktkategorie: Instrumente und Geräte für die Dermatologie und Kosmetik
The MPTflex is a medical tomograph based on femtosecond multiphoton excitation of fluorescent biomolecules like NAD(P)H, flavins, porphyrins, elastin, and melanin. The extracellular matrix protein collagen can be identified by its second harmonic generation (SHG). Autofluorescence and SHG signals are recorded by fast PMT detectors with single photon sensitivity.
The tomograph consists of a compact, turn-key tunable femtosecond near infrared (NIR) laser, an articulated arm with NIR optics, a beam- scanning module with galvoscanners and piezo -driven optics, a two-PMT-detector module as well as a control unit including JenLab Image software for image processing. An additional module for two-photon in-vivo FLIM as well as two-photon microendoscopy can be provided.
Applications The major application is early diagnosis of skin diseases such as malignant melanoma. Using innovative non-invasive multiphoton technology the physician obtains optical biopsies with detailed information on living cells and tissue structures within their physiological environment. Dermatological disorders can be detected with submicron spatial resolution. The image acquisition time is less than 10 seconds per frame. The novel tomograph MPTflex has the potential to revolutionize the conventional invasive time consuming diagnostic procedures. The multiphoton tomograph can also be used in tissue engineering and wound healing studies as well as in cosmetic and pharmaceutical research. The efficiency of anti-aging products as well as the biosafety of sunscreen nanoparticles can be tested in vivo. Furthermore, the skin age can be evaluated by measuring the ratio of elastin to collagen.
Flexible in-vivo multiphoton tomography
In vivo optical biopsies with subcellular spatial resolution based on near infrared femtosecond laser technology for:
- melanoma detection - diagnostics of dermatological disorders - tissue engineering - cosmetic research, skin aging - in situ drug monitoring - animal research studies - stem cell research - detection of fluorescent proteins
Technical data compact turn-key tunable Ti:Sapphire femtosecond laserlaser pulse width: 200 fs repetition frequency: 80 MHz in situ laser power: 2-50 mW wavelength range. 710-920 nm full-frame scanning, region-of-interest (ROI) scanning, line scanning, single-point illumination (spot scan) typical scan range: 350 μm x 350 μm (horizontal); 200 μm (vertical) spatial resolution: < 0.5 μm (horizontal); < 2 μm (vertical) focusing optics: magnification 40x NA 1.3 control and image processing software (JenLab Scan, JenLab Image) operating temperature 15-35°C relative humidity: 5-65 % power requirements: 230 VAC (50 Hz) or 115 VAC (60 Hz) 710 mm x 960 mm x 1400 mm, 250 kg The system requires an air-conditioned room with reduced ambient light.
Notes: These specifications are subject to change without notice.
JenLab provides femtosecond laser technology for medicine, biotechnology and cell biology. Clinical in vivo optical biopsies with subcellular spatial resolution and chemical information based on near infrared femtosecond laser technology can be obtained with the CE marked Multiphoton Tomographs DermaInspect, the SPIE Prism awarded MPTflex and MPTflex CARS.
Applications include label-free skin imaging / in vivo histology for early cancer diagnosis, determination of the skin aging, detection of intratissue cosmetics and pharmaceutics such as sunscreen nanoparticles (in situ drug monitoring), tomograph guided surgery as well as space medicine. Multiphoton Tomographs have been used to track stem cells, neurons and cancer cells in small animals.
Further JenLab products are microscopes and endoscopes for fluorescence lifetime FLIM imaging (TauMap), sub-100nm material processing and nanosurgery (FemtoCut), femtosecond laser transfection for stem cell manipulation (femtOgene), cryomicroscopy (Cryo 2PM), two-photon microendoscopy (2P Endoscope) and two-photon microscopy (2PM).